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KMID : 0352519850220010365
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Korea Univercity Medical Journal
1985 Volume.22 No. 1 p.365 ~ p.373
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An Immunohistochemical Study on Carcinoembryonic Antigen, Secretory Component and Secretory IgA in Normal and Carcinomatous Gastric Mucosa
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朴石俊/Lim, Suk Joon
李大一/金世民/Lee, Dale/Kim, Sae Min
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Abstract
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Gastric carcinomas have been divided by some experts into intestinal type and gastric infilt.iative categories based on the predominant cell type in the neoplasm. It is argued that this subdivision has pathogenic and clinical significance. Intestinal type lesions are more often of the expanding type associated with chronic gastritis and the consequent intestinal metaplasia seen in chronic gastritis. In addition, pre-and postoperative measurement of carcinoembryonic antigen (CEA) in tumor cell or serum have shown prognostic value.
An additional recent line of research is immunohistochemical investigation of epithelial marker antigen. These include functional characteristics of the normal epithelium, which may disappear partly or completely during malignant development. Secretory component (SC) and secretory IgA in epithelium of Lieberkiihn crypt belong to this category. Thus, the functional role of SC as an epithelial receptor for dimeric IgA for the purpose of local immunologic defence in normal colon might be lost in carcinomatous lesion of the colon. As far as SC and IgA are concerned, biologic behavior of normal or malignant gastric epithelial cell is not understood well.
Therefore, for the purpose to compare distribution of .SC in normal and carcinomatous gastric lesion, each 5 cases of formalin fixed and paraffin embedded blocks of well and moderately differentiated expanding type of adenocarcinoma and infiltrative carcinomas of stomach were selected respectively and immunoperoxidase staining. of Avidin-Biotin-Complex method was performed using antihuman CEA, SC, and. IgA antisera and distrib-Won of each antigen between normal and carcinomatous gastric mucosa was compared.
The results obtained are as follows;
1. In normal gastric mucosae, anti SC-, and anti-CEA antisera showed negative reactions and there were many plasma cells which react, to anti IgA antiserum in the lamina propria.
2. On the mucosal cells of intestinal metaplasia, Anti SC-and anti IgA antisera showed positive reaction, except goblet cells.
3. Strong positive reactions with anti-SC, anti-IgA and anti-CEA antisera were noted in the cells of well differentiated adenocarcinoma.
4. Negative reaction with anti-SC, anti-IgA, and anti CEA antisera were noted in the cells of poorly differentiated infiltrative type of gastric adenocarinoma.
With the above result, SC seems to be a useful indicator to confirm adenocarcinoma of stomach arising from intestinalized epithelial cells.
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